![]() ![]() A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa. Step-by-step dosing and administration 1 For dosing, choose either the low dose or high dose based on the specific factor Xa (FXa) inhibitor, strength of last dose of factor Xa (FXa) inhibitor, and time since the patient's last dose of factor Xa (FXa) inhibitor per the table below. Anticoagulant reversal for life-threatening bleeds.FDA approved in May 2018, limited availability June 2018 with broader commercial launch in early 2019.Inhibits the activity of the Tissue Factor Pathway Inhibitor (TFPI), increasing tissue factor-initiated thrombin generation.Binds and sequesters factor Xa inhibitors Clinical efficacy is based upon reversal of anti-FXa-activity in healthy volunteers dosed with apixaban or rivaroxaban.Dosage Forms: solution reconstituted, 100 mg per vialĪdult Dosing Determined by last dose, type of factor Xa inhibitor, and dose of inhibitorĤ00 mg IV bolus at rate of ~30 mg/minute, followed 2 minutes later by 4 mg/minute for up to 120 minutesĨ00 mg IV bolus at rate of ~30 mg/minute, followed 2 minutes later by 8 mg/minute for up to 120 minutes.Type: factor Xa inhibitor reversal, antidote.2.1 Determined by last dose, type of factor Xa inhibitor, and dose of inhibitor Patients will receive one of two dosing regimens of andexanet alfa based on which FXa inhibitor they received and the amount and timing of the most recent dose. ![]()
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